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Fig 1. Skin Cross Section
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Transdemal Delivery Technology
Transdermal Drug Delivery is defined as movement of substances (e.g. drugs) across stratum
corneum (outer layer of skin) into systemic circulation (blood). In other words, it delivers
active ingredients through the skin and directly to the desired area to achieve a better result.
Advantages of Transdemal Delivery
With the skin regarded as the impeccable external protective barrier of our body,
many are sceptical of the true efficacy of transdermal delivery, especially for a
hydrophilic nutrient. There are two schools of thought. One uses synthetic liposomes
to encapsulate the nutrient and penetrate the skin – which is essentially a lipid
bilayer. Another relies on natural oils to carry the nutrient and penetrate the skin
to enter the blood stream. Lynk Biotechnologies believes that with the right
formulation of natural oils, an effective transdermal delivery of health supplements
is possible.
Transdermal offers a number of advantages over the oral delivery:
- Reduce drug breakdown by by-passing the
digestive system. Therefore, it requires much lower dosage compared to
oral route.
- Minimize side effects. For example,
transdermal estradiol patch doesn't cause liver damage compared to oral
estradio pills.
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